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pentobarbital will reduce the extent or result of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Prevent coadministration of lefamulin with powerful or reasonable CYP3A inducers Unless of course the gain outweighs hazards. Watch for lessened efficacy.​​​​​​​​​​​​​â